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Transcranial Doppler Ultrasound During Critical Illness in Children: Survey of Practices in Pediatric Neurocritical Care Centers*
Conclusions: At least 27 pediatric neurocritical care centers use transcranial Doppler during clinical care. In the majority of centers, studies are performed and interpreted by credentialed personnel, and findings are used to guide clinical management. Further studies are needed to standardize these practices.
Source: Pediatric Critical Care Medicine - January 1, 2020 Category: Pediatrics Tags: Neurocritical Care Source Type: research

Core outcomes sets for studies evaluating critical illness and patient recovery
This article provides an update on COS projects in critical care medicine, and related resources and tools for COS developers. Recent findings We identified 28 unique COS projects, of which 15 have published results as of May 2020. COS topics relevant to critical care medicine include mechanical ventilation, cardiology, stroke, rehabilitation, and long-term outcomes (LTOs) after critical illness. There are four COS projects for coronavirus disease 2019 (COVID-19), with a ‘meta-COS’ summarizing common outcomes across these projects. To help facilitate COS development, there are existing resources, standards, guidelin...
Source: Current Opinion in Critical Care - September 3, 2020 Category: Nursing Tags: CRITICAL CARE OUTCOMES: Edited by Stephen Brett Source Type: research

Paroxysmal sympathetic hyperactivity in neurological critical care
Conclusion: PSH is an unusual complication in neurocritical care. It prolonged the hospitalization and hampers recovery. The other life-threatening conditions that mimic PSH should be excluded. The association with JE and tuberculous meningitis was not previously described in literature.
Source: Indian Journal of Critical Care Medicine - January 6, 2015 Category: Intensive Care Authors: Rajesh VermaPrithvi GiriImran Rizvi Source Type: research

Targeted temperature management: Current evidence and practices in critical care
Saurabh Saigal, Jai Prakash Sharma, Ritika Dhurwe, Sanjay Kumar, Mohan GurjarIndian Journal of Critical Care Medicine 2015 19(9):537-546Targeted temperature management (TTM) in today's modern era, especially in intensive care units represents a promising multifaceted therapy for a variety of conditions. Though hypothermia is being used since Hippocratic era, the renewed interest of late has been since early 21 st century. There have been multiple advancements in this field and varieties of cooling devices are available at present. TTM requires careful titration of its depth, duration and rewarming as it is associate...
Source: Indian Journal of Critical Care Medicine - September 8, 2015 Category: Intensive Care Authors: Saurabh SaigalJai Prakash SharmaRitika DhurweSanjay KumarMohan Gurjar Source Type: research

High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru
CONCLUSION: Cerebrovascular events associated with COVID-19 in pediatric patients, including infants, must be recognized as one of the more severe presentations of this infection in pediatric patients.IMPACT: Pediatric patients with COVID-19 can present with hemorrhagic and ischemic strokes on presentation. Neurological presentation in pediatric patients with COVID-19 has high mortality. Mortality of pediatric patients with COVID-19 is associated with comorbidities. Pediatric presentation and outcomes of COVID-19 in different regions can be novel to previously described.PMID:33941862 | PMC:PMC8090521 | DOI:10.1038/s41390-021-01547-x
Source: Pediatric Research - May 4, 2021 Category: Pediatrics Authors: Alvaro Coronado Munoz Jaime Tasayco Willy Morales Luis Moreno David Zorrilla Angie Stapleton Patricia Pajuelo Giuliana Reyes Matilde Estupi ñan Ricardo Seminario Manuel Ortiz Jes ús Domínguez Source Type: research

Development and Validation of an Empiric Tool to Predict Favorable Neurologic Outcomes Among PICU Patients*
Conclusions: This proposed prediction tool encompasses 20 risk factors into one probability to predict favorable neurologic outcome during ICU stay among children with critical illness. Future studies should seek external validation and improved discrimination of this prediction tool.
Source: Critical Care Medicine - December 19, 2017 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

Low Predictability of Three Different Noninvasive Methods to Determine Fluid Responsiveness in Critically Ill Children
Conclusions: Dynamic preload variables such as stroke volume variation or respiratory variations in vena cava inferior diameter may not be useful for predicting fluid responsiveness in certain pediatric patient populations. Esophageal Doppler peak velocity was predictive of fluid responsiveness where a target value of more than 135,5 cm/s may be a signal to terminate further fluid challenges. This target value may be different in different age groups, as esophageal Doppler peak velocity varies with age.
Source: Pediatric Critical Care Medicine - March 1, 2015 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Polyneuropathy in Critically Ill Mechanically Ventilated Children: Experience From a Tertiary Care Hospital in North India*
Conclusions: We observed a high prevalence of critical illness polyneuropathy in children in PICU, mechanically ventilated for 7 days or more; almost all of whom had underlying sepsis.
Source: Pediatric Critical Care Medicine - September 1, 2019 Category: Pediatrics Tags: Neurocritical Care Source Type: research

Progesterone for Neuroprotection in Pediatric Traumatic Brain Injury
Conclusions: The unique features of the developing brain from that of a mature adult brain make it necessary to independently study progesterone in clinically relevant, immature animal models of traumatic brain injury. Additional preclinical studies could lead to the development of a novel neuroprotective therapy that could reduce the long-term disability in head-injured children and could potentially provide benefit in other forms of pediatric brain injury (global ischemia, stroke, and statue epilepticus).
Source: Pediatric Critical Care Medicine - March 1, 2015 Category: Pediatrics Tags: Neurocritical Care Source Type: research

The Use of Clevidipine for Hypertension in Pediatric Patients Receiving Mechanical Circulatory Support
Conclusions: In this pediatric cardiac cohort, clevidipine infusions were effective at hypertension management and were not associated with hypotensive or code events. This report details the largest cohort and longest duration of clevidipine administration within a pediatric population and did not demonstrate hypotensive events, even among neonatal populations. Clevidipine may be a reasonable cost-effective alternative antihypertensive medication compared to traditional short-acting agents.
Source: Pediatric Critical Care Medicine - December 1, 2020 Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

Intracranial Electroencephalography in Pediatric Severe Traumatic Brain Injury
Conclusions: These findings suggest that intracranial electroencephalography may be useful for detection of secondary insult development in children with traumatic brain injury.
Source: Pediatric Critical Care Medicine - March 1, 2020 Category: Pediatrics Tags: Neurocritical Care Source Type: research

Hospital-Associated Venous Thromboembolism in a Pediatric Cardiac ICU: A Multivariable Predictive Algorithm to Identify Children at High Risk
Objectives: Critically ill children with cardiac disease are at significant risk for hospital-associated venous thromboembolism, which is associated with increased morbidity, hospital length of stay, and cost. Currently, there are no widely accepted guidelines for prevention of hospital-associated venous thromboembolism in pediatrics. We aimed to develop a predictive algorithm for identifying critically ill children with cardiac disease who are at increased risk for hospital-associated venous thromboembolism as a first step to reducing hospital-associated venous thromboembolism in this population. Design: This is a pr...
Source: Pediatric Critical Care Medicine - June 1, 2020 Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

Should Transfusion Trigger Thresholds Differ for Critical Care Versus Perioperative Patients? A Meta-Analysis of Randomized Trials
Conclusions: The safety of restrictive transfusion strategies likely differs for critically ill patients versus perioperative patients. Further trials investigating transfusion strategies in the perioperative setting are necessary.
Source: Critical Care Medicine - January 17, 2018 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research